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. 2005 Oct;126(4):353–363. doi: 10.1085/jgp.200509312

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Copyright © 2005, The Rockefeller University Press

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Figure 3. — (A) β-cells from KCNE1 null mice lacking cardiac type I_Ks delayed rectifier K⁺ channels also express AZ-sensitive K_slow currents. Top traces show representative K_slow currents from KCNE1 (−/−) mouse β-cells, both β-cells from KCNE1 (+/+) and KCNE1 (−/−) mice are sensitive to AZ. Bottom bar graph shows no difference of mean K_slow currents in KCNE1 (+/+) and KCNE1 (−/−) mice (n = 38–45, P > 0.05), AZ significantly inhibited K_slow currents in both group mice (**, P < 0.01, n = 6). (B) β-cells from KCNQ1 null mice lacking cardiac type I_Ks delayed rectifier K⁺ channels still have AZ-sensitive K_slow currents. Top traces show representative K_slow currents from KCNQ1 (−/−) mouse β-cells. Both β-cells from KCNQ1 (+/+) and KCNQ1 (−/−) mice are sensitive to AZ. Bottom bar graph shows no difference of mean K_slow currents in KCNQ1 (+/+) and KCNQ1 (−/−) (P > 0.05, n = 12), AZ significantly inhibited K_slow currents in both groups of mice (*, P < 0.05, n = 5).