Figure 3.
Mgi modulation of CaV1.2 channels with EF-hand mutation D1546N. (A) Typical current traces of cells expressing mutant D1546N exposed to a range of Mgi. The trace at 0.8 mM Mgi in each pair is from the same series of experiments as the trace at a different Mgi concentration in the right hand column. (B) Effect of changes in Mgi on tail current amplitude normalized as in Fig. 1 to the mean Itail for WT at 0.26 mM Mgi. Bracket illustrates WT Range as in Fig. 1. (C) Effect of Mgi on voltage dependence of activation measured as in Fig. 1. (D) Effect of Mgi on the voltage dependence of inactivation measured as in Fig. 1.