Figure 7.
Mgi modulation of CaV1.2 channels with the EF-hand mutation K1543D. (A) Typical current traces of cells expressing Cav1.2 EF-hand mutant K1543D exposed to a range of Mgi. (B) Effect of Mgi on tail current amplitude normalized as in Fig. 1 to the mean Itail for WT at 0.1 mM Mgi. Bracket illustrates WT Range as in Fig. 1. (C) Effect of Mgi on the voltage dependence of activation measured as in Fig. 1. (D) Effect of Mgi on the voltage dependence of inactivation measured as in Fig. 1.