TABLE I.
Functional Characteristics of the Rabbit NKCC2 Splice Variants Expressed in X. laevis Oocytes
| Km values (in mM)
|
||||
|---|---|---|---|---|
| Na+ | Rb+ | Cl− | Distribution along the TAL | |
| NKCC2B | 10 | 2 | 10 | Macula densa cells |
| NKCC2A | 10 | 2 | 25 | Cortex and outer stripe of the OM |
| NKCC2F | 60 | 5 | 100 | Inner stripe of the OM |
The Kms shown represent estimated values based on two independent studies (Gimenez et al., 2002; Gagnon et al., 2003) and the localization data is based on in situ hybridization studies (Igarashi et al., 1995). Here, TAL = thick ascending limb of the loop of Henle, and OM = outer medulla.