Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Oct;126(4):393–412. doi: 10.1085/jgp.200509346

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2005, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 2. — The effects of β1 are both Ca²⁺ and voltage dependent. (A–C) Ca²⁺ dose–response curves determined for the BK_α and BK_α+β1 channel at (A) −40, (B) 0, and (C) +40 mV. Curves are fitted with the hill equation:

=.

Fit parameters are as follows: −40 mV, BK_α (Kd = 36.5 μM, n = 1.24); BK_α+β1(Kd = 6.89 μM, n = 2.7); 0 mV, BK_α (Kd = 22.1 μM, n = 1.5); BK_α+β1 (Kd = 3.4 μM, n = 1.9); +40 mV, BK_α (Kd = 7.25 μM, n = 1.6); BK_α+β1(Kd = 3.68 μM, n = 1.5). (D–G) G–V relations are shown for the BK_α and the BK_α+β1 channel at (D) 100 μM Ca²⁺, (E) 10 μM Ca²⁺, (F) 1 μM Ca²⁺, and (G) 3 nM Ca²⁺. The curves are fitted with Boltzmann functions as described in the legend to Fig. 1.

Inline graphic — The effects of β1 are both Ca²⁺ and voltage dependent. (A–C) Ca²⁺ dose–response curves determined for the BK_α and BK_α+β1 channel at (A) −40, (B) 0, and (C) +40 mV. Curves are fitted with the hill equation:

=.

Fit parameters are as follows: −40 mV, BK_α (Kd = 36.5 μM, n = 1.24); BK_α+β1(Kd = 6.89 μM, n = 2.7); 0 mV, BK_α (Kd = 22.1 μM, n = 1.5); BK_α+β1 (Kd = 3.4 μM, n = 1.9); +40 mV, BK_α (Kd = 7.25 μM, n = 1.6); BK_α+β1(Kd = 3.68 μM, n = 1.5). (D–G) G–V relations are shown for the BK_α and the BK_α+β1 channel at (D) 100 μM Ca²⁺, (E) 10 μM Ca²⁺, (F) 1 μM Ca²⁺, and (G) 3 nM Ca²⁺. The curves are fitted with Boltzmann functions as described in the legend to Fig. 1.