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. 2005 Oct;126(4):379–392. doi: 10.1085/jgp.200509355

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Copyright © 2005, The Rockefeller University Press

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Figure 10. — Effect of itr-1(sy327) gain-of-function mutation on Ca²⁺ oscillation arrhythmia induced by RNAi-mediated loss of EGL-8 or PLC-3 activity. (A) Calcium oscillations in intestines isolated from a itr-1(sy327);plc-3(RNAi) and itr-1(sy327);egl-8(RNAi) worm. Oscillations are largely normal in the itr-1(sy327);plc-3(RNAi) intestine, but arrhythmic in the intestine isolated from an itr-1(sy327);egl-8(RNAi) worm. (B) Coefficients of variance for Ca²⁺ oscillations observed in intestines from glo-1, itr-1(sy327), itr-1(sy327);plc-3(RNAi) and itr-1(sy327);egl-8(RNAi) worms. itr-1(sy327) suppresses Ca²⁺ oscillation arrhythmia induced by RNAi of plc-3, but not arrhythmia induced by egl-8(RNAi). Values are means + SEM (n = 4–7). *, P < 0.001 compared with glo-1 and itr-1(sy327). **, P < 0.01 compared with itr-1(sy327);plc-3(RNAi).