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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Biomaterials. 2007 Oct 30;29(5):597–606. doi: 10.1016/j.biomaterials.2007.10.011

Figure 1.

Figure 1

Schematic representation of non-immunogenic, targeted adhesion using ultrasound radiation force (USRF) and microbubbles engineered with the buried ligand architecture (BLA). (Top) Before the acoustic pulse: the microbubble is stealth as it travels to the site of interest. The polymeric overbrush of the BLA shields the ligand from serum components, such as complement proteins, red blood cells (RBCs) and white blood cells (WBCs). (Right) During the acoustic pulse, ultrasound radiation force pushes the microbubble against the endothelium and oscillation reveals the ligand for binding to the target receptor. Multiple ligand-receptor interactions result in targeted adhesion, but only within the beam focus.