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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2007 Nov 26;1781(1-2):36–39. doi: 10.1016/j.bbalip.2007.11.003

Fig. 3.

Fig. 3

Disease phenotypes in LmnaHG/+ mice with FTI treatment. (a and b) Body weight curves for male (a) and female (b) LmnaHG/+ and littermate Lmna+/+ mice treated with an FTI or vehicle alone, beginning at four weeks of age. The body weight curves for FTI-treated LmnaHG/+ mice were significantly different than those of the vehicle-treated LmnaHG/+ mice, both in males and in females (P < 0.0001, as judged by the repeated-measure analysis of variance method). (c) Spontaneous rib fractures in male (squares) and female (circles) FTI- and vehicle-treated LmnaHG/+ mice at the time that they died. The FTI-treated mice had fewer fractures (P < 0.0001 for both males and females).