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. 2008 Mar 19;3(3):e1839. doi: 10.1371/journal.pone.0001839

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Moghadas et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — Simulations were seeded with an initial treatment level of (a) 85%; (b) 78% (optimal level); (c) 50%; (d) 25%, and then changed to the level shown on the horizontal axis at the time displayed on the vertical axis (corresponding to the time-course of the epidemic). The color bars illustrate the total number of clinical cases due to all strains, relative to that generated when the optimal constant treatment level (78% in this case) is implemented.

Simulations were seeded with an initial treatment level of (a) 85%; (b) 78% (optimal level); (c) 50%; (d) 25%, and then changed to the level shown on the horizontal axis at the time displayed on the vertical axis (corresponding to the time-course of the epidemic). The color bars illustrate the total number of clinical cases due to all strains, relative to that generated when the optimal constant treatment level (78% in this case) is implemented.