Table 2.
Merlin-expressing and merlin-deficient meningioma cells
| Meningioma sample | Merlin expressionb | WHO grade | Histological subtypec |
|---|---|---|---|
| MN34 | (-) | benign | fibroblastic |
| MN256 | (-) | benign | fibroblastic |
| MN258 | (-) | benign | transitional |
| MN261 | (-) | benign | fibroblastic |
| MN290 | (-) | atypical | meningothelial |
| MN297 | (-)a | atypical | ND |
| MN302 | (-) | benign | transitional |
| MN304 | (-) | benign | fibroblastic |
| MN307 | (-) | benign | ND |
| MN310 | (-) | benign | fibroblastic |
| MN320 | (-) | atypical | ND |
| MN324 | (-) | benign | ND |
| MN327 | (-) | benign | transitional |
| MN336 | (-) | benign | ND |
| MN350 | (-) | benign | transitional |
| MN355 | (-) | benign | ND |
| MN357 | (-) | benign | fibroblastic |
| MN359 | (-) | ND | ND |
| MN363 | (-) | benign | ND |
| MN47 | (+) | benign | transitional |
| MN276 | (+) | benign | meningothelial |
| MN291 | (+) | atypical | ND |
| MN298 | (+) | malignant | ND |
| MN299 | (+) | benign | meningothelial |
| MN318 | (+) | atypical | transitional |
| MN319 | (+) | atypical | fibroblastic |
| MN330 | (+) | benign | transitional |
| MN332 | (+) | benign | ND |
| MN349 | (+) | benign | ND |
| MN354 | (+) | benign | ND |
a
molecular weight significantly lower than wild-type merlin, consistent with expression of a stable truncation product.
b
expression determined by immunoblotting.
c
ND-not determined.