Table 2. Univariate and multivariate Cox regression analyses by cortactin expression levels.

Cortactin status	Mean time to recurrence (months)	Percentage of recurrence (95% confidence interval)	Hazard ratio (95% confidence interval)	P
Univariate
Local recurrence
Overexpressor	32.0	49.1% (39–66)	6.032 (1.6–27.1)	0.014
Nonoverexpressor	47.0	28.0% (16–49)	0.169 (0.05–0.8)
Disease-free survival
Overexpressor	22.2	61.5% (40–81)	2.586 (1.2–5.9)	0.007
Nonoverexpressor	34.7	17.5% (11–29)	0.379 (0.3–0.8)
Overall survival
Overexpressor	29.2	57.8% (35–80)	2.275 (1.2–4.7)	0.024
Nonoverexpressor	42.5	20.9% (11–30)	0.425 (0.3–0.9)
Multivariate
Variable	Hazard ratio	95% confidence interval		P
Local recurrence
Tumour type	1.675	0.8–3.7	—	0.20
TNM stage	1.412	0.8–2.4	—	0.20
Histologic grade	0.965	0.6–1.6	—	0.90
Cortactin overexpressor	5.293	1.2–23.6	—	0.029*
Disease-free survival
Tumour type	1.616	0.9–3.0	—	0.13
TNM stage	1.453	1.0–2.1	—	0.06
Histologic grade	1.033	0.7–1.5	—	0.87
Cortactin overexpressor	3.000	1.3–7.0	—	0.010*
Overall survival
Tumour type	1.648	0.9–3.1	—	0.12
TNM stage	1.679	1.1–2.5	—	0.014*
Histologic grade	0.984	0.7–1.5	—	0.94
Cortactin overexpressor	2.449	1.1–5.7	—	0.038*

TNM=tumour node metastasis.

^*Significant at the 0.05 level.