Table 3.

Tumor Rapamycin Levels

	24 hours			48 hours
Treatment Groups	Rapamycin Level (ng/ml)	p value*	Number of Mice	Rapamycin Level (ng/ml)	p value**	Number of Mice
Treatment Trial (Tumor bearing)
0.4% Direct Topical Rapamycin	13.8 ± 0.7	0.12	3	14.2 ± 1.8	0.33	3
0.8% Indirect Topical Rapamycin	34.2 ± 9.6	0.37	3	25.8 ± 7.8	0.65	3
0.8% Direct Topical Rapamycin	59.6 ± 23.5	N/A	3	21.0 ± 5.9	N/A	3
0.16 mg Rapamycin IP	421.8 ± 119.4	0.03	2	323.7 ± 98.1	0.03	2

* Compared to 0.8% direct treatment 24 hr tumor level.

** Compared to 0.8% direct treatment 48 hr tumor leve