Table 1.
Subject characteristics and preinfusion hormone concentrations
| Endpoints | Eugonadal | Hypogonadal | P value |
|---|---|---|---|
| Age (yr) | 22.7 ± 0.71 | 22.8 ± 1.3 | NS |
| BMI (kg/m2) | 25.8 ± 0.92 | 24.8 ± 0.98 | NS |
| LH (IU/liter) | 2.9 ± 0.27 | 1.3 ± 0.33 | 0.002 |
| FSH (IU/liter) | 1.8 ± 0.25 | 2.0 ± 0.38 | NS |
| GH (μg/liter) | 0.60 ± 0.22 | 0.62 ± 0.23 | NS |
| IGF-I (μg/liter) | 384 ± 22 | 425 ± 56 | NS |
| IGFBP-1 (μg/liter) | 21 ± 4.4 | 12 ± 2.7 | 0.05 |
| IGFBP-3 (μg/liter) | 4432 ± 142 | 4560 ± 258 | NS |
| E2 (pmol/liter) | 87 ± 7.3 | 30 ± 3.0 | <0.0001 |
| Te (nmol/liter) | 19 ± 1.7 | 1.8 ± 0.04 | <0.0001 |
| SHBG (nmol/liter) | 20 ± 2.4 | 20 ± 3.0 | NS |
Data are the mean ± sem (n = 12 eugonadal and n = 10 hypogonadal men). P values are one-tailed under the a priori hypothesis that sex steroid deprivation reduces GH-related measures.