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Mean LH levels in healthy male volunteers (A) and GnRH-deficient men on GnRH therapy (B) during medical castration for 7 d with either no sex steroid add-back or replacement with T or E2 from d 4–7. Values represent the mean of samples drawn every 10 min for 12 h. a, Significant difference from BL, P < 0.005; b, significant difference from BL, P < 0.05; c, significant difference between d 3–4 and d 6–7, P < 0.05; d, significant difference between d 3–4 and d 6–7, P < 0.005.
