Table 1.

Summary of key studies on sex steroid regulation of LH secretion in men

Ref.	Steroid regimen	Subjects	Mean LH	LH amp	LH frequency
Finkelstein et al. (1)	T 15 mg/d × 4 d	Normal men GnRH-deficient men	↓58% ↓28%	↓ ↓	↓ EC
Finkelstein et al. (2)	E2 90 μg/d × 4 d	Normal men GnRH-deficient men	↓52% ↓42%	↓ ↓	↓ EC
Schnorr et al. (3)	KC with T patch 7.5 mg/d, KC with E2 patch 50 μg/d, KC with T patch plus AI	Normal men	↑ 3-fold after KC; ↓ to BL with T or E2 No change after T plus AI	Not assessed	Not assessed
Bagatell et al. (4)	T 15 mg/d × 3 d E290 μg/d × 3 d DHT 500 μg/d × 3 d	GnRH-deficient men	↓40% ↓55% no change	Not assessed	EC
Santen et al. (24)	E2 3.5 μg/h × 6 h T 600 μg/h × 6 h	Normal men	↓21% ↓18%	↓ ↑	No Δ ↓

AI, Aromatase inhibitor; EC, experimentally controlled.