Skip to main content
. 2007 Dec 11;93(3):1062–1071. doi: 10.1210/jc.2007-1525

Figure 4.

Figure 4

Structural predictions of LHX3 and LHX4 HD/DNA interactions. Models of LHX3 and LHX4 interaction with target DNAs were performed using the Engrailed HD/DNA complex as a template (21). A, Ribbon model of wild-type LHX4 HD/DNA with leucine 190 shown in space filling format. The predicted positions of the amino (N) and carboxyl (C) termini of the full protein are shown. B, Predicted LHX4 HD with an arginine at position 190. Different rotamers for this residue are possible. In this prediction there is contact with the V201 residue within the third α-helix of the HD (arrow), destabilizing the structure and inhibiting DNA binding. C, Ribbon model of wild-type LHX3 HD/DNA with alanine 210 highlighted. D, Predicted LHX3 HD/DNA with a valine at position 210. E, Ribbon model of wild-type LHX4 HD/DNA with alanine 210 highlighted. F, Predicted LHX4 HD with a proline at position 210. Note the altered configuration of the carboxyl terminus (C) (arrow).