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. 2008 Mar 13;118(4):1491–1501. doi: 10.1172/JCI33467

Figure 2. Priapic activity seen in Ada–/– mice is dependent on elevated adenosine in the penis.

Figure 2

(A) Adenosine levels were elevated in the penes of Ada–/– mice. Inset bar graph shows the average adenosine levels from 3 Ada–/– mice and 3 wild-type mice. Data are means ± SEM (n = 3). *P < 0.005 versus Ada+. (B) The prolonged penile erection in Ada–/– mice was corrected by intraperitoneal injection of PEG-ADA. n = 3–5. (C) Representative recordings of EFS-induced CCS relaxation (5 V and 30 Hz) using 10 μM phenylephrine–precontracted CCSs of Ada+ mice and Ada–/– mice treated with or without PEG-ADA. (D–F) Average EFS-induced relaxation from the phenylephrine-precontracted CCSs of Ada+ mice, Ada–/– mice, and Ada–/– mice treated with PEG-ADA. EFS-induced changes in the force of CCS relaxation (D), the duration of relaxation (E), and the combination of force and duration (area under baseline; F). Data are means ± SEM (n = 5–6). *P < 0.05 versus Ada+; **P < 0.05 versus untreated Ada+; ***P < 0.05 versus untreated Ada–/–.