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. 2008 Mar 13;118(4):1491–1501. doi: 10.1172/JCI33467

Figure 8. Priapic activity in SCD transgenic mice is dependent on elevated adenosine in penis and A2BR signaling.

Figure 8

(A) Adenosine levels were elevated in the penes of SCD transgenic mice. Data are means ± SEM (n = 5–6). *P < 0.005 versus control. (B) Increased CCS relaxation by EFS in SCD transgenic mice. Data are means ± SEM (n = 5). P < 0.05, SCD transgenic versus control. (C–E) Prolonged penile erection in SCD transgenic mice is due to A2BR signaling. EFS-induced relaxation in CCSs (C), duration of relaxation (D), and the combination of force and duration (area under baseline; E) were measured by force transducer in mice left untreated or treated with PEG-ADA, MRS1706, or ZM241389. Data are means ± SEM (n = 5). *P < 0.05 versus control; **P < 0.05, versus untreated SCD transgenic; ***P < 0.05 versus untreated control.