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. Author manuscript; available in PMC: 2008 Mar 12.
Published in final edited form as: J Am Chem Soc. 2007 Dec 20;130(2):410–411. doi: 10.1021/ja0775467

Scheme 1.

Scheme 1

Steps Involved in the Nanoparticle-Based Potentiometric Detection of DNA Hybridizationa

a (A) Formation of a mixed monolayer of DNA probe on gold substrate; (B) hybridization with target DNA; (C) second hybridization with CdS-labeled probe; (D) dissolution of the CdS tag, followed by detection using a Cd2+-selective electrode.