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The JNK1/p38 – ATF2/Elk-1 bifan motif configuration and its immediate environment. (a) The basic motif is in the shaded area. (b) The shaded area is the bifan motifs with an adjacent link from JNK to c-Jun. JNK phosphorylates and activates c-Jun. (c) The shaded area includes a positive feedback loop involving the immediate early gene c-Jun. (d) The shaded area includes a negative feedback loop involving the immediate early gene MKP-1.
