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. 2008 Jan 4;94(7):2566–2579. doi: 10.1529/biophysj.107.116673

FIGURE 9.

FIGURE 9

Dynamics of free monomeric activated transcription factors (TF) in a bifan motif configuration adjacent to a positive feedback loop and nested in a negative feedback loop. The full bifan configuration as shown in Fig. 1d (top panel); after eliminating the links from p38 to ELK1 and from JNK1 to ATF2 (middle panel); and without the links from p38 to ATF2 and from JNK1 to ELK1 (bottom panel). The initial conditions were: [p38] = [JNK] = 3 μM, [ATF2] = [ELK1] = 30 μM, and [c-Jun] = 10 μM. OR gates were assumed for all substrate activations. Cartoons of the network are presented by each panel. The signal inputs are presented at the most upper panel.