TABLE 1.

Model parameters

Symbol	Value	Parameter
kP (N·m·rad−1)	6.0 × 10−16	Rotational stiffness of stereociliary rootlet
kGS,max (mN·m−1)	4	Stiffness of tip link complex (gating spring)
kSA (mN·m−1)	0.2	Stiffness of horizontal connectors
f0 (pN)	25	Intrinsic force difference between open and closed states
kb (ms−1μM−1)	0.2	Ca-binding coefficient
KD (μM)	20	Ca dissociation constant
kF (ms−1)	12	C→O rate constant
kR (ms−1)	15	O→C rate constant
η	0.9	Coefficient in Eqs. 3 and 4
b1 (nm)	1	Gating swing
b2 (nm)	5	Channel release on binding Ca2+
rK	0 (0.8)*	Fraction of gating spring stiffness reduction as Ca2+ bound
fCa (pN)	10	Change in force to open channel on binding Ca2+
FM (pN)	20	Maximal stalling force per channel by the adaptation motor
CFA (μM)	0.1 (3–100)	[Ca2+] near the channel when a channel was closed (open)
r12	3	[Ca2+] ratio between the two adaptation sites (CSA/CFA)
kA (nm·ms−1 pN−1)	0.02 (0.05)†	Rate constant for myosin-driven adaptation
αM (μM−2)	0.0125	Constant in Eq. 9
Q	2	Constant in Eq. 9

^*r_K = 0.8 in Fig. 8 B; elsewhere, r_K = 0.

^†k_A was increased to 0.05 for simulations in Figs. 10 and 11.