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Orb6 kinase is proposed to be part of a regulatory cascade contributing to the mitotic control and responding to the Ras1 and Cdc42-dependent morphological control pathway via the Pak1/Shk1 kinase. Orb6 kinase regulates independently cell morphogenesis and the cell cycle, mediating its effect on p34cdc2 kinase directly through the Wee1 protein kinase or through some other mechanism dependent on p34cdc2 tyrosine phosphorylation.
