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(a) Acute in vivo effects of one single dose of sildenafil (5 mg kg−1 by gavage, 2 h before harvesting the aorta) on acetylcholine-induced, endothelium-dependent and (b) endothelium-independent vasorelaxation stimulated by the NO donor DEA-NONOate in aortic rings from control and diabetic (STZ) rats. Data are means±s.e.mean from 10 to 15 experiments, **P<0.01 vs STZ untreated. DEA-NONOate, 2-(N,N-diethylamino)-diazenolate-2-oxide; STZ, streptozotocin.
