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. 2008 Jan 28;153(5):1022–1029. doi: 10.1038/sj.bjp.0707587

Figure 1.

Figure 1

Effects of oxygen/glucose deprivation (OGD) on field excitatory postsynaptic potentials (fEPSPs) evoked by electrical stimulation of the stratum radiatum in the CA1 hippocampal region. The recovery of fEPSP amplitude following 9 min (n=9) or 14 min (n=15) of OGD. Exposure to 9 min of OGD (black circles) causes a transient fEPSP depression that was always reversible after returning to normal oxygenated artificial cerebral spinal fluid (ACSF), whereas exposure to 14 min of OGD (grey circles) caused an fEPSP depression that was always irreversible even after a prolonged re-exposure to normal oxygenated ACSF. Each point represents fEPSP amplitude expressed as percentage of the mean baseline responses recorded before OGD application. Bars indicate the time duration of OGD. Insets display representative traces immediately before the OGD and at the end of the experiment.