Figure 4.

Catalase is involved in the protective effect of H₂O₂. (a) Pooled data from six experiments showing that the protective effect of H₂O₂ (3 mM) was prevented by superfusion, both in pretreatment and during oxygen/glucose deprivation (OGD), with the catalase inhibitor 3-amino-1,2,4-triazole (3-AT; 20 mM), suggesting that the protective role of H₂O₂ was mediated by catalase. The field excitatory postsynaptic potential (fEPSP) traces were taken at the time points indicated by numbers in the corresponding graph. (b) Treatment of slices with 3-AT alone was not able to alter fEPSPs recorded from slices exposed to 9 min of OGD compared to control conditions (n=6).