Table 1.
(Vascular) smooth muscles in which SERCA pump inhibitors raise [Ca2+]i and/or elicit contraction
| Species | Smooth muscle | Remarks | Responses | References |
|---|---|---|---|---|
| Rat | Aorta | Abolished by nifedipine/nicardipine | Contraction and increased [Ca2+]i | Tepel et al., 1994; Kwan et al., 1994; Low et al., 1994; Noguera et al., 1997; Tosun et al., 1998; Xuan and Glass, 1996 |
| Carotid artery | Partially reduced by verapamil | Contraction and increased [Ca2+]i | Sekiguchi et al., 1996 | |
| Coronary artery | No contraction and increased [Ca2+]i | Snetkov et al., 2003 | ||
| Femoral artery | Partially reduced by verpamil | Contraction and increased [Ca2+]i | Nomura et al., 1997 | |
| Femoral artery | A small transient contraction and increased [Ca2+]i | Snetkov et al., 2003 | ||
| Mesenteric artery | No contraction and increased [Ca2+]i | Snetkov et al., 2003 | ||
| Pulmonary artery | Unaffected by nifedipine, verapamil reduced by tyrosine kinase inhibitors. pCa2+/tension curve unaffected | Gonzalez De La Fuente et al., 1995 | ||
| Pulmonary distal arterial smooth muscle | Abolished by nifedipine | Increased [Ca2+]i | Wang et al., 2004 | |
| Intrapulmonary artery | Unaffected by diltiazem or the reverse mode Na+/Ca2+ antiport inhibitor KB-R7943 | Contraction and increased [Ca2+]i | Snetkov et al., 2003 | |
| Renal cortical interlobar arteries | Increased [Ca2+]i | Facemire et al., 2004 | ||
| Renal artery | No contraction | Snetkov et al., 2003 | ||
| Preglomerular vascular smooth muscle | Increased [Ca2+]i | Fellner and Arendshorst, 1999 | ||
| Basilar arteries | Unaffected by verapamil | Contraction | Bergdahl et al., 2005 | |
| Ileum | Unaffected by nifedipine, methoxyverapmail | Increased [Ca2+]i | Ohta et al., 1995 | |
| Spleen | Unaffected by nifedipine reduced by tyrosine kinase inhibitors | Burt et al., 1995 | ||
| Urinary bladder | Very weak contractile | Munro and Wendt, 1994 | ||
| A7r5 rat smooth muscle cell line | Not applicable | Increased [Ca2+]i | Byron and Taylor, 1995; Iwamuro et al., 1999; Iwasawa et al., 1997 | |
| Mouse | Anococcygeus | Partially reduced by nifedipine | Contraction and increased [Ca2+]i | Gibson et al., 1994; Wallace et al., 1999 |
| Guinea-pig | Gastric fundus | Partially reduced by nifedipine | Petkov and Boev, 1996a | |
| Cat | Gastric fundus | Partially reduced by nifedipine | Petkov and Boev, 1996b | |
| Canine | Pulmonary arterial smooth muscle cells | Unaffected by nifedipine reduced by tyrosine kinase inhibitors | Contraction and increased [Ca2+]i | Doi et al., 2000; Wilson et al., 2002 |
| Renal arterial smooth muscle cells | Unaffected by nisoldipine reduced by tyrosine kinase inhibitors | Contraction and increased [Ca2+]i | Wilson et al., 2002 | |
| Rabbit | Pulmonary arterial smooth muscle cells | Unaffected by nifedipine | Increased [Ca2+]i | Kang et al., 2003 |
| Carotid artery smooth muscle | Increased [Ca2+]i | Kawanabe et al., 2002 | ||
| Pial artery | Contraction and increased [Ca2+]i | Flemming et al., 2002, 2003 | ||
| Choroidal artery | Abolished by nifedipine | Increased [Ca2+ ]i | Curtis and Scholfield, 2001 | |
| Human | Lower oesophageal sphinctor smooth muscle | Increased [Ca2+ ]i | Wang et al., 2003 | |
| Bronchus | Cortijo et al., 1997 | |||
| Porcine | Airway smooth muscle | Increased [Ca2+ ]i | Ay, 2004 | |
| Swine | Renal artery | Increased [Ca2+ ]i | Utz et al., 1999 | |
| Prostate cell line | Increased [Ca2+ ]i | Thebault et al., 2005 |
Abbreviation: SERCA, sarcoplasmic/endoplasmic reticulum Ca2+ ATPases.