Figure 4.

Effects of the vehicle (20% hydroxypropyl β cyclodextrin) or JNJ 26993135 in oral doses of 5, 15 and 30 mg kg⁻¹, b.i.d., on the colonic TNF-α activity, expressed as pg per mg protein (upper panel) and colonic IL-6 levels expressed as pg per mg protein (lower panel). Measurements were taken 3 days after intracolonic challenge with trinitrobenzenesulphonic acid. The values from the non-challenged control group (con) are also shown. Results are expressed as mean±s.e.mean (n=8 rats), where statistical significance is given as ^*P<0.05, ^**P<0.01, ^***P<0.001 compared with the vehicle (veh) group.