Table 1.

Population pharmacokinetic parameters and inter- and intra-individual variability of diclofenac after i.p., p.o. and i.v. administration based on model 1 (Figure 1a)

Parameters	Estimate	IIV %
	Fixed effects	Random effects
k20* (min−1)	0.728 (60)	39 (50)
V2 (ml)	8.5 (74)
k32** (min−1)	0.048 (23)
k23 (min−1)	0.857 (60)
Frequency (min)	330 (1)
F1 (%) p.o.	72.1 (25)
k43 (min−1)	5.12 (38)	15 (99)
k45 (min−1)	3.23 (41)	47 (67)
k54 (min−1)	0.0061 (30)
k27 (min−1)	0.184 (183)
k72 (min−1)	0.0139 (57)
Residual error
Proportional parent (%)	39 (38)
Proportional metabolite (%)	20 (45)

Values in parentheses are relative standard errors (in percent) of the estimates. IIV % is inter-individual variability in percent.

^*k₂₀ equals k₄₀.

^**k₃₂ equals k₁₃ equals k₃₄. F₃ and k₆₃ were fixed at 1 and 1000 min⁻¹, respectively.