Table 1. Comparison of inhibitory kinetics of His–centerin with thrombin, plasmin and trypsin, with or without GAGs.
UH, unfractionated heparin; CS, chondroitin sulfate.
| Protease | Condition | n | SI | ka (M−1·s−1) | ka×SI |
|---|---|---|---|---|---|
| Thrombin | Control | 3 | 2.57±0.04 | 1.17±0.094×103 | 3.00×103 |
| UH (1 unit/ml) | 3 | 3.83±0.01 | 5.21±0.460×103 | 2.0×104 | |
| UH (2.5 units/ml) | 3 | 3.74±0.10 | 1.14±0.175×104 | 4.26×104 | |
| UH (5 units/ml) | 3 | 3.55±0.14 | 1.45±0.027×104 | 5.15×104 | |
| CS (20 μg/ml) | 3 | 3.15±0.15 | 2.36±0.072×103 | 7.43×103 | |
| Plasmin | Control | 3 | 1.72±0.05 | 1.92±0.18×103 | 3.30×103 |
| UH (10 units/ml) | 2 | 2.87±0.21 | 1.54±0.05×103 | 4.42×103 | |
| Trypsin | Control | 3 | 2.12±0.09 | 1.90±0.06×105 | 4.02×105 |
| UH (10 units/ml) | 2 | 3.23±0.16 | 1.76±0.14×105 | 5.68×105 |