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. 2007 Jul 13;405(Pt 3):407–415. doi: 10.1042/BJ20070319

Figure 3. Expression of Bax or Bak in Bax/Bak DKO MEFs restores susceptibility to Bnip3-mediated mitochondrial dysfunction and cell death.

Figure 3

(A) Representative bright-field (upper panel) and fluorescence (YoPro-1; lower panel) images of Bax/Bak DKO MEFs transfected with the indicated construct. (B) Significant loss of TMRM fluorescence in Bax/Bak DKO MEFs transfected with Bax or Bak together with Bnip3. (C) Bax and Bak restored Bnip3-mediated cell death as measured by permeability to YoPro-1. Results are means±S.E.M., n=3 (*,**P<0.05 compared with Bax or Bak alone).