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. 2007 Jul 13;405(Pt 3):407–415. doi: 10.1042/BJ20070319

Figure 5. Bnip3 induces mitochondrial fragmentation and release of cytochrome c in WT MEFs but not in Bax/Bak DKO MEFs.

Figure 5

(A) WT or Bax/Bak DKO MEFs were co-transfected with vector or Bnip3 and MitoDsRed2 for 24 h and then stained with an antibody towards cytochrome c and examined by immunofluorescence. Representative images are shown. (B) Quantification of cytochrome c release. Results are means±S.E.M., n=4 (*P<0.05 compared with control). (C) Overexpression of Bnip3 induces fragmentation of the mitochondrial network in WT MEFs. (D) Recruitment of Drp-1 to mitochondria in WT MEFs overexpressing Bnip3.