Figure 6. Inhibition of the mPTP reduces Bnip3-mediated mitochondrial dysfunction, but does not prevent activation of Bax and Bak.

(A) WT MEFs transfected with vector or Bnip3 were treated with 2 μM CsA or 100 μM BA and stained with TMRM to assess ΔΨ_m after 24 h (*,**P<0.05 compared with Bnip3 alone). WT MEFs transfected with vector or Bnip3 and treated with CsA were fixed after 24 h and stained with (B) anti-Bax(NT) or (C) anti-Bak(NT). Results are means±S.E.M., n=3.