Figure 7. Inhibition of mPTP opening with CsA does not prevent Bnip3-induced translocation of GFP–Bax to mitochondria.

(A) Bax/Bak DKO MEFs were co-transfected with vector or Bnip3 plus GFP–Bax and then treated with CsA for 24 h before being analysed by fluorescence microscopy. Images shown are representative of results obtained in three separate experiments. (B) Quantification of the percentage cells with either diffuse or mitochondrial GFP–Bax fluorescence. Results are means±S.E.M., n=3.