Figure 4. Inhibitors of PfNMT in vitro reduce P. falciparum parasitaemia in culture.

Each inhibitor was applied to synchronized mid-trophozoite erythrocytic stages of P. falciparum (27 h) at 100 μM and 10 μM and the culture was allowed to grow until controls had reached a similar stage in the following cycle (approx. 48 h later). The total parasitaemia of each sample was evaluated by microscopic assessment of Giesma-stained blood smears. Values are means±S.D. for three experiments. All experiments were initiated at a parasitaemia of approx. 1%. RBC, red blood cell.