Figure 8. Antagonist effects of peptide Pc variants carrying single-site mutations.

(A) Various Pc peptide variants generated by alanine scanning were tested at 1.5 (□) or 15 (■) μM for their antagonist effect on the association of CK2 subunits as described in Figure 7(C). Results are the means±S.D. (n=3) of a representative experiment. WT, wild-type. (B) IC₅₀ values determined for each peptide variant.