Table 4.
Effect of 100 days of overfeeding on lipoprotein fractions in relation to the I405V CETP genotype.
| Variable | V405V, n=8 Mean (SE) * | I405V, n=10 Mean (SE) | I405I, n=6 Mean (SE) | P value |
|---|---|---|---|---|
| Cholesterol (mmol/l) | ||||
| Before | 4.5 (0.4) | 4.9 (0.3) | 3.9 (0.3) | NS |
| Change † | 0.8 (0.7) | 0.2 (0.3) | 0.3 (0.1) | NS |
| Triglycerides (mmol/l) | ||||
| Before | 1.22 (0.40) | 1.21 (0.08) | 0.97 (0.26) | NS |
| Change † | 0.86 (0.76) | 0.69 (0.26) | 0.26 (0.24) | NS |
| VLDL-C (mmol/l) | ||||
| Before | 0.44 (0.18) | 0.47 (0.06) | 0.34 (0.08) | NS |
| Change † | 0.39 (0.38) | 0.16 (0.10) | 0.11 (0.11) | NS |
| VLDL-apo B (mg/dl) | ||||
| Before | 6.5 (1.7) | 7.7 (1.8) | 5.3 (0.7) | NS |
| Change † | 6.6 (4.1) | 4.4 (1.6) | 1.7 (0.9) | NS |
| LDL-C (mmol/l) | ||||
| Before | 2.7 (0.3) | 3.3 (0.3) | 2.4 (0.3) | 0.02 |
| Change † | 0.4 (0.3) | 0.2 (0.2) | 0.3 (0.1) | NS |
| ApoB (mg/dl) | ||||
| Before | 69.5 (6.9) | 90.1 (7.2) | 64.3 (5.6) | 0.004 |
| Change † | 19.4 (13.3) | 12.0 (7.0) | 4.8 (3.0) | NS |
| HDL-C (mmol/l) | ||||
| Before | 1.31 (0.08) | 1.08 (0.09) | 1.17 (0.01) | 0.02 |
| Change † | −0.04 (0.08) | −0.12 (0.05) | −0.11 (0.02) | 0.01 |
| Adjusted change ‡ | 0.02 (0.04) | −0.16 (0.03) | −0.12 (0.04) | 0.02 |
| HDL2 (mmol/l) | ||||
| Before | 0.51 (0.06) | 0.40 (0.03) | 0.45 (0.03) | NS |
| Change † | 0.01 (0.06) | −0.02 (0.03) | −0.07 (0.03) | 0.05 |
| Adjusted change ‡ | 0.03 (0.03) | −0.04 (0.02) | −0.08 (0.03) | 0.04 |
| HDL3 (mmol/l) | ||||
| Before | 0.80 (0.02) | 0.68 (0.08) | 0.73 (0.03) | NS |
| Change † | −0.04 (0.02) | −0.10 (0.05) | −0.03 (0.02) | 0.0004 |
| Adjusted change ‡ | −0.004 (0.02) | −0.13 (0.02) | −0.04 (0.02) | 0.002 |
| HDL-apo A-I (mg/dl) | ||||
| Before | 123.8 (10.0) | 103.2 (3.2) | 105.0 (1.3) | 0.005 |
| Change † | −4.6 (11.4) | −3.7 (2.5) | −3.7 (2.4) | 0.05 |
| Adjusted change ‡ | 2.7 (5.5) | −7.0 (4.4) | −7.9 (5.2) | NS |
*
Values are means (SE), using the mean value of each twin pair
NS: No significant differences between genotypes were observed.
†
Change: Post-overfeeding minus pre-overfeeding values.
‡
Adjusted change: Post-overfeeding minus pre-overfeeding values adjusted for baseline, baseline VLDL-TG and VLDL-TG change with overfeeding.