Figure 1.

Composite schematic of endogenous meiotic inhibitor 2 regulation in vertebrates. Details of selected interactions are described in the text. APC, anaphase promoting complex; Calm, calmodulin; Camk2, calmodulin-dependent kinase 2; Can, calcineurin; Cdc2/20, cell division cycle 2/20 homologues, respectively; Cdc2:Cycb, maturation promoting factor; Cycb, cyclin B; Emi2, endogenous meiotic inhibitor 2; IP₃, inositol 1,4,5-trisphosphate; IP₃R_c, closed IP₃ receptor; IP₃R_o, open IP₃ receptor; Mapk, mitogen-activated protein kinase; Mek, mitogen-activated protein kinase kinase; PIP₂, phosphatidylinositol 4,5-bisphosphate; Plcz1, phospholipase C-zeta; Plk1, polo-like kinase 1; PP2A, protein phosphatase 2A; Rsk, ribosomal s6 kinase; SCF, Skp1– Cullin– F-box-containing E3 ubiquitin ligase complex; Trcp1b, F-box protein β-transducin repeat containing protein 1b; Ub, ubiquitin; P, phosphate; *, active form; Δ[Ca²⁺]_i, increase in the intracellular free calcium ion concentration.