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. 2007 Sep 12;407(Pt 1):101–111. doi: 10.1042/BJ20070364

Figure 2. Schematic representation of the human NHE2 promoter and core promoter region.

Figure 2

The promoter region between nucleotide −1051 to the ATG codon at +316 (with respect to the TIS shown by a bent arrow) including the location of the potential regulatory elements is shown. The region corresponding to bp −85 to +150 is amplified and the sequences of the GC-box centred at position −25 (containing potential overlapping binding sites for three Sp1 and one EGR-1), the TIS, an overlapping AP2/Sp1 binding site at +60 and an E-box at +113 are shown. The arrows in the TIS oligonucleotide represent the palindromic sequence. The TIS is shown as +1. C/GCTGC/G repeats are underlined. The boxes drawn around nucleotide sequences mark the core sequence of the protein binding sites as indicated.