Table 4.

Allele frequencies of the polymorphisms associated with melanogenesis, Hirschsprung disease, AMD, and the ability to taste PTC.

		Melanogenesis	Hirschsprung	AMD		Ability to Taste PTC
Gene Name:		SLC24A5	RET	CFH	LOC387715	TAS2R38	TAS2R38	TAS2R38
Nucleotide Change:		g.13242G>A	g.9349G>A	g.37989T>C	g.205G>T	g.144G>C	g.784C>T	g.885A>G
	n	G	T	C	T	C	C	G
Mother Tongue
Assamese	26	0.260	0.240	0.360	0.200	0.340	0.360	0.360
Bengali	27	0.293	0.207	0.276	0.397	0.310	0.310	0.310
Gujarati	181	0.208	0.271	0.333	0.375	0.313	0.313	0.313
Hindi	29	0.105	0.209	0.267	0.244	0.349	0.360	0.360
Kannada	24	0.268	0.232	0.304	0.464	0.196	0.250	0.250
Kashmiri	24	0.020	0.100	0.260	0.340	0.480	0.500	0.500
Konkani	43	0.058	0.250	0.385	0.269	0.308	0.308	0.308
Malayalam	25	0.259	0.259	0.222	0.500	0.259	0.296	0.296
Marathi	26	0.296	0.259	0.278	0.204	0.407	0.407	0.426
Marwari	25	0.041	0.273	0.265	0.334	0.384	0.398	0.406
Oriya	27	0.154	0.346	0.212	0.250	0.346	0.365	0.365
Parsi	25	0.100	0.300	0.300	0.380	0.280	0.280	0.300
Punjabi	28	0.052	0.293	0.431	0.414	0.328	0.310	0.328
Tamil	29	0.036	0.179	0.250	0.393	0.339	0.321	0.375
Telugu	28	0.000	0.188	0.167	0.354	0.417	0.417	0.417
FST		0	0.011	0.009	0	0.009	0.010	0.011
p-value		1	1	1	1	1	1	1
Gender
Female	237	0.110	0.232	0.268	0.348	0.331	0.338	0.342
Male	339	0.117	0.261	0.289	0.330	0.363	0.376	0.386
FST		0.049	0.020	0.037	0.042	0.020	0.007	0
p-value		0.825	0.887	0.847	0.837	0.887	0.933	1
Population
Cohort	576	0.114	0.249	0.280	0.338	0.350	0.360	0.368
Standard Error		0.028	0.015	0.018	0.024	0.018	0.017	0.017
HWE Constant		0.004	0.003	0.009	0.006	0.002	0.002	0.002
p-value		0.304	0.654	0.350	0.513	0.926	0.855	0.857
Welch modified t-test:
Africa		4.21 × 10-14				3.86 × 10-4	3.24 × 10-8	0.005
Europe		2.80 × 10-4		4.20 × 10-3	0.068	2.43 × 10-6	5.78 × 10-5	1.37 × 10-4
Asia		7.18 × 10-14		1.55 × 10-8	0.018	0.055	7.97 × 10-6	7.60 × 10-6
Americas		0.024				0.006	1.92 × 10-5	1.64 × 10-5
Oceania						0.090	0.009	0.003

P-values significant at <0.05 are shown in bold.