Table 5.
The allele frequencies of human leukocyte antigen-DRB1 (HLA-DRB1) in the patients with Kawasaki disease and the control subjects
| HLA alleles | Healthy controls (n = 159) n (%) | KD patients (n = 74) n (%) | Coronary complications | |
|---|---|---|---|---|
| Present (n = 21) n (%) | Absent (n = 53) n (%) | |||
| HLA-DRB1 | ||||
| 01 | 29 (18.2) | 8 (10.8) | 1 (4.8) | 7 (13.2) |
| 03 | 7 (4.4) | 1 (1.4) | 0 (0.0) | 1 (1.9) |
| 04 | 48 (30.2) | 30 (40.5) | 6 (28.6) | 24 (45.3)a |
| 07 | 26 (16.4) | 8 (10.8) | 1 (4.8) | 7 (13.2) |
| 08 | 32 (20.1) | 14 (18.9) | 3 (14.3) | 11 (20.8) |
| 09 | 28 (17.6) | 12 (16.2) | 7 (33.3)b | 5 (9.4) |
| 10 | 4 (2.5) | 4 (5.4) | 2 (9.5) | 2 (3.8) |
| 11 | 10 (6.3) | 8 (10.8) | 5 (23.8)c | 3 (5.7) |
| 12 | 18 (11.3) | 11 (14.9) | 2 (9.5) | 9 (17.0) |
| 13 | 32 (20.1) | 10 (13.5) | 3 (14.3) | 7 (13.2) |
| 14 | 21 (13.2) | 10 (13.5) | 3 (14.3) | 7 (13.2) |
| 15 | 35 (22.0) | 20 (27.0) | 5 (23.8) | 15(28.3) |
| 16 | 4 (2.5) | 2 (2.7) | 1 (4.8) | 1 (1.9) |
KD, Kawasaki disease; RR, relative risk
ap < 0.05; RR = 1.9 (95% confidence interval [CI], 0.96–3.82) vs healthy control subjects
bp < 0.04 between KD patients with and without coronary complication
cp < 0.04; RR = 4.7 (95% CI, 1.26–17.17) vs healthy control subjects