Fig. 1.

Two representative batch cultures ([Glc]₀ = 5.5 mM, [Gln]₀ = 2.1 mM and [Glc]₀ = 11 mM, [Gln]₀ = 1.7 mM) of 55-6 hybridoma cells: (a) viable cell density and monoclonal antibody concentration; (b) glucose and lactate concentrations; (c) glutamine and ammonium concentrations. In (a), solid lines show Eq. (1) predictions and dashed lines Eq. (2) predictions. In b, c, all lines show Eq. (2) predictions. Experimental data are given as the average of duplicate cultures ± SD