Table 2.
Effect of cell engineering on cell cycle and productivity
| Contributor | Cell line and recombinant product | Effectors | Specific productivity (Qp) (fold increase) |
|---|---|---|---|
| Fussenegger et al. (1997) | CHO SEAP | p21CIP1 or p27KIP1 or p53175P | 10 |
| Fussenegger et al. (1998) | CHO SEAP | p21CIP1 | 10–15 |
| Mazur et al. (1998) | CHO SEAP | p21CIP1, p27KIP1 or p53175P | 10–15 |
| Fussenegger et al. (1998) | CHO SEAP | p27KIP1 + Bcl-2 | 30 |
| Kaufmann et al. (2001) | CHO SEAP | p27KIP1 and reduced temperature culture (30°C) | 2–3 |
| Watanabe et al. (2002) | NS0 human-mouse chimeric IgG4 antibody | p21CIP1 | >4 |
| Meents et al. (2002) | CHO soluble intercellular adhesion molecule (sICAM) | p27KIP1 | 5 |
| Ibarra et al. (2003) | NS0 chimeric antibody | p21CIP1 | 4 |
| Carvalhal et al. (2003) | CHO SEAP | p27KIP1 | 4 |
| Bi et al. (2004) | CHO human-mouse chimeric IgG4 antibody | p21CIP1 | ∼4 |