Table 1.

Functional annotation of defined patient subgroups.

M			N1			N2
category	n	p	category	n	p	category	n	p
DAVID IDs
	258			383			238
Biological processes
	230			344			203
DNA replication	13	5E-3	endodome transport	7	1E-3	development	38	9E-3
taxis	9	7E-3	vacuole organization and biogenesis	7	9E-3	reactive oxygen species metabolism	6	1E-2
carbohydrate metabolism	25	9E-3	response to chemical stimuli	23	1E-2	response to oxidatïve stress	5	3E-2
negative regulation of biological processes	26	1E-2	regulation of enzyme activity	20	3E-2	dephosphorylation	6	2E-2
nucleic acid metabolism	69	2E-2	vesicle mediated transport	18	3E-2	intracellular protein transport	18	3E-2
Molecular function
	238			347			211
DNA binding	39	2E-2	protein dimerization activity	14	2E-2	protein domain specific binding	6	3E-2
protein dimerization activity	10	5E-2	hydrolase activity on glycosyl bonds	12	5E-2	GTPase activity	7	5E-2
nucleic acid binding	54	5E-2
Cellular component
	285			342			195
chromosome	11	2E-3	vacuole	44	2E-8	chromosome	8	4E-2
chromatin	7	9E-3	lytic vacuole	39	2E-7
nucleus	70	6E-3	lysosome	39	1E-7	lytic vacuole	17	4E-2
lytic vacuole	20	2E-3	extracellular region	32	2E-2	lysosome	17	4E-2
lysosome	20	2E-3	endosome	8	4E-2	non-membrane bound organelle	28	4E-2
KEGG pathway
	122			185			125
N-glycan degradation	5	2E-2	antigen processing	9	2E-3	Toll-like receptor signaling	10	2E-2
hematopoetic cell lineage	8	3E-2	glycosphingolipid metabolism	7	2E-2	glycosylaminoglycan degradation	6	2E-2
			hematopoetic cell lineage	10	4E-2
Biocarta pathway
	68			92			57
cyclins and cell cycle regulation	9	2E-2	role of ERB2 in signal transduction	9	5E-3	activation of Src	4	3E-2
			IL 3 signaling pathway	7	1E-2	phospholipid signaling intermediates	5	4E-2
			IL 6 signaling pathway	8	1E-2
			Erk and PI-3 kinase pathway	7	2E-2
			signaling pathway from G-protein families	7	3E-2

"n", number of genes involved in the corresponding annotation category; p, modified Fisher exact p-value of the gene enrichment for each category.