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. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: Am J Physiol Gastrointest Liver Physiol. 2007 Sep 6;293(5):G995–1003. doi: 10.1152/ajpgi.00537.2006.

Fig. 5.

Fig. 5

Effects of absolute IRS-1 deficiency on muscularis overgrowth induced by SMP8-IGF-I transgene. Muscularis mass in colon in IRS-1+/+/WT (closed bar), IRS-1+/+/SMP8-IGF-I (gray bar), IRS-1−/−/WT (hatched bar), or IRS-1−/−/SMP8-IGF-I (cross-hatched bar) mice. Histograms show absolute values for wet weight, DNA, and protein content per centimeter expressed as means ± SE; n = 12. Numbers above histograms show mean values in SMP8-IGF-I mice expressed as a percentage of values in WT mice of same IRS-1 genotype. Results of 2-way ANOVA are shown, where *P < 0.001 and NS = P > 0.05. Two-way ANOVA revealed significant main effects of SMP8-IGF-I transgene and significant main effects of absolute IRS-1 deficiency but no significant interaction. ANOVA analyses are described in more detail in supplemental material, available on American Journal of Physiology-Gastrointestinal and Liver Physiology website.