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. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: Am J Physiol Gastrointest Liver Physiol. 2007 Sep 6;293(5):G995–1003. doi: 10.1152/ajpgi.00537.2006.

Fig. 6.

Fig. 6

IRS-1 is required for antiapoptotic but not proliferative effects of transgene-derived IGF-I. Histograms show levels of spontaneous mitoses (A) and apoptosis (B) in colonic mucosa of IRS-1+/+/WT (closed bar), IRS-1+/+/MT-hIGF-I (gray bar), IRS-1−/−/WT (hatched bar), and IRS-1−/−/MT-hIGF-I mice (cross-hatched bar). Numbers above histograms show magnitude of significant changes observed in MT-hIGF-I transgenics relative to WT mice of same IRS-1 genotype. Note that IRS-1+/+/MT-hIGF-I mice showed reduced apoptosis compared with IRS-1+/+/WT but that apoptosis in IRS-1−/−/MT-hIGF-I mice did not differ significantly from IRS-1−/−/WT mice. Results of 2-way ANOVA are shown below histograms, where *P < 0.05 for main effect of MT-hIGF-1 transgene, IRS-1 gene deletion, or interaction between transgene and IRS-1 deletion. NS = P > 0.05; n = 100 crypts assayed in at least 4 mice of each genotype.