. Author manuscript; available in PMC: 2008 Nov 1.

Published in final edited form as: Am J Physiol Gastrointest Liver Physiol. 2007 Sep 6;293(5):G995–1003. doi: 10.1152/ajpgi.00537.2006.

Table 3.

Mean levels of IGF-IR, IRS-2, and Shc in small intestine or colon mucosa and muscularis of IRS-1^−/− mice expressed as a ratio of values in IRS-1^+/+ littermates

	Mucosa	Muscularis
Small Intestine
IGF-IR	0.9±0.08	0.7±0.12
IRS-2	0.5±0.14	0.5±0.10
Shc	1.4±0.26	1.4±0.20
Colon
IGF-IR	1.3±0.28	1.4±0.40
IRS-2	1.1±0.19	1.1±0.35
Shc	1.4±0.09^*	1.8±0.26^*

Data are means ± SE; n ≥ 4 independent analyses on extracts prepared from different littermate pairs. Signal intensities for each mediator in IRS-1^−/− extracts were expressed as ratio of values in corresponding mucosal or muscularis extract of IRS-1^+/+ littermate evaluated in same immunoprecipitation/immunoblot experiment. IGF-IR, insulin-like growth factor-I receptor; Shc, Src homology 2 domain and collagen protein. Wilcoxon signed rank tested whether ratios differed from 1;

P < 0.05.