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. Author manuscript; available in PMC: 2008 Mar 16.
Published in final edited form as: Neuropharmacology. 2007 Jan 20;52(6):1336–1341. doi: 10.1016/j.neuropharm.2007.01.005

Fig. 2.

Fig. 2

Buprenorphine induced locomotor sensitization in wild-type but not in MOP knockout mice. Mice lacking the MOP [MOP (−/−)] and their wild-type littermates [MOP (+/+)] were tested on day 1 as described under legend to Fig. 1. The same treatment was given for 4 additional consecutive days. Mice were then left undisturbed until day 11 (test day). On the test day, mice were habituated to the motor activity cambers for 1 h, then injected with buprenorphine (3 mg/kg, s.c.) and motor activity recorded for an additional 1 h (4 × 15-min sessions). Data are presented as mean (±S.E.M.) of 6 wild-type (A) and 6 MOP knockout (B) mice.