. Author manuscript; available in PMC: 2009 Mar 1.

Published in final edited form as: Biochim Biophys Acta. 2007 Dec 23;1782(3):127–150. doi: 10.1016/j.bbadis.2007.12.005

Table 3.

Properties of human tumor viruses

Virus	Viral Taxonomy	Genome	Cell Tropism	Human Cancers
EBV	Herpesviridae	dsDNA 172kb ~90 ORFs	Oropharyngeal epithelial cells, B-cells	BL, NPC, lymphomas
HBV	Hepadnoviridae	dsDNA 3.2kb 4 ORFs	Hepatocytes, white blood cells	HCC
HCV	Flaviviridae	dsRNA 9.4 kb 9 ORFs	Hepatocytes	HCC
HPV	Papillomavirdae	dsDNA 8 kb 8–10 ORFs	Squamous epithelial cells	Cervical, oral, and anogenital cancer
HTLV-1	Retroviridae	dsRNA 9.0 kb 6 ORFs	T-cells	ATL
KSHV	Herpesviridae	dsDNA 165kb ~90ORFs	B-cells	Kaposi sarcoma, primary effusion lymphoma

ATL, adult T-cell leukemia; BL, Burkitt’s lymphoma; EBV, Epstein-Barr virus; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HPV, human papillomavirus; HTLV-1, human T-cell leukemia virus; KSHV, Kaposi’s sarcoma-associated herpesvirus; NPC, nasopharyngeal carcinoma