Figure 3.

Comparison of the B cell epitope of O. volvulus tropomyosin with the equivalent region of tropomyosins from other organisms. The deduced amino acid sequence shown is that of the shortest peptide recognized by IgG in serum from mice vaccinated with a PBS extract of microfilariae. Aligned are representative sequences from nematodes, an insect, and mammals. The IgE-binding epitope of shrimp tropomyosin also is shown. Amino acids identical to those of the O. volvulus epitope are represented by a dot.